Alex Rins wygrywa Grand Prix Stanów Zjednocznych na torze w Austin w Teksasie! Podium uzupełnia Luca Marini dla, którego było to pierwsze podium w karierze w wyścigu MotoGP i Fabio Quartararo.
| POS | RIDER | NAT | TEAM | TIME/DIFF |
| 1 | Alex Rins | SPA | LCR Honda (RC213V) | 41m 14.649s |
| 2 | Luca Marini | ITA | Mooney VR46 Ducati (GP22) | +3.498s |
| 3 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +4.936s |
| 4 | Maverick Viñales | SPA | Aprilia Racing (RS-GP23) | +8.318s |
| 5 | Miguel Oliveira | POR | RNF Aprilia (RS-GP22) | +9.989s |
| 6 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP22) | +12.049s |
| 7 | Johann Zarco | FRA | Pramac Ducati (GP22) | +12.242s |
| 8 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +20.399s |
| 9 | Fabio Di Giannantonio | ITA | Gresini Ducati (GP22) | +27.981s |
| 10 | Augusto Fernandez | SPA | Tech3 GASGAS (RC16)* | +28.217s |
| 11 | Michele Pirro | ITA | Ducati Lenovo (GP23) | +32.370s |
| 12 | Jonas Folger | GER | Tech3 GASGAS (RC16) | +68.065s |
| 13 | Brad Binder | RSA | Red Bull KTM (RC16) | +83.012s |
| Stefan Bradl | GER | Repsol Honda (RC213V) | DNF | |
| Takaaki Nakagami | JPN | LCR Honda (RC213V) | DNF | |
| Joan Mir | SPA | Repsol Honda (RC213V) | DNF | |
| Francesco Bagnaia | ITA | Ducati Lenovo (GP23) | DNF | |
| Jack Miller | AUS | Red Bull KTM (RC16) | DNF | |
| Raul Fernandez | SPA | RNF Aprilia (RS-GP22) | DNF | |
| Alex Marquez | SPA | Gresini Ducati (GP22) | DNF | |
| Aleix Espargaro | SPA | Aprilia Racing (RS-GP23) | DNF | |
| Jorge Martin | SPA | Pramac Ducati (GP23) | DNF |