Mistrz Świata, Francesco Bagnaia po wygranej w wyścigu sprinterskim dopisze sobie zwycięstwo w wyścigu głównym na torze Portimao w Portugalii. Drugie miejsce zdobywa Maverick Vinales, podium uzupełnia Marco Bezzecchi.
| POS | RIDER | NAT | TEAM | TIME/DIFF |
| 1 | Francesco Bagnaia | ITA | Ducati Lenovo (GP23) | 41m 25.401s |
| 2 | Maverick Viñales | SPA | Aprilia Racing (RS-GP23) | +0.687s |
| 3 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP22) | +2.726s |
| 4 | Johann Zarco | FRA | Pramac Ducati (GP22) | +8.060s |
| 5 | Alex Marquez | SPA | Gresini Ducati (GP22) | +8.125s |
| 6 | Brad Binder | RSA | Red Bull KTM (RC16) | +8.247s |
| 7 | Jack Miller | AUS | Red Bull KTM (RC16) | +8.381s |
| 8 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +8.543s |
| 9 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP23) | +9.294s |
| 10 | Alex Rins | SPA | LCR Honda (RC213V) | +11.591s |
| 11 | Joan Mir | SPA | Repsol Honda (RC213V) | +16.992s |
| 12 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +17.448s |
| 13 | Augusto Fernandez | SPA | Tech3 GASGAS (RC16)* | +21.723s |
| 14 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +27.050s |
| Raul Fernandez | SPA | RNF Aprilia (RS-GP22) | DNF | |
| Luca Marini | ITA | Mooney VR46 Ducati (GP22) | DNF | |
| Jorge Martin | SPA | Pramac Ducati (GP23) | DNF | |
| Fabio Di Giannantonio | ITA | Gresini Ducati (GP22) | DNF | |
| Miguel Oliveira | POR | RNF Aprilia (RS-GP22) | DNF | |
| Marc Marquez | SPA | Repsol Honda (RC213V) | DNF |