Jack Miller wygrywa niedzielny wyścig Grand Prix Japonii na torze Motegi! Drugie miejsce zdobywa Brad Binder, trzeci linię mety przekroczył Jorge Martin.
| POS | RIDER | NAT | TEAM | TIME/DIFF |
| 1 | Jack Miller | AUS | Ducati Lenovo (GP22) | 42m 29.174s |
| 2 | Brad Binder | RSA | Red Bull KTM (RC16) | +3.409s |
| 3 | Jorge Martin | SPA | Pramac Ducati (GP22) | +4.136s |
| 4 | Marc Marquez | SPA | Repsol Honda (RC213V) | +7.784s |
| 5 | Miguel Oliveira | POR | Red Bull KTM (RC16) | +8.185s |
| 6 | Luca Marini | ITA | Mooney VR46 Ducati (GP22) | +8.348s |
| 7 | Maverick Viñales | SPA | Aprilia Racing (RS-GP) | +9.879s |
| 8 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +10.193s |
| 9 | Enea Bastianini | ITA | Gresini Ducati (GP21) | +10.318s |
| 10 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP21)* | +16.419s |
| 11 | Johann Zarco | FRA | Pramac Ducati (GP22) | +16.586s |
| 12 | Pol Espargaro | SPA | Repsol Honda (RC213V) | +17.456s |
| 13 | Alex Marquez | SPA | LCR Honda (RC213V) | +18.219s |
| 14 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +19.012s |
| 15 | Cal Crutchlow | GBR | WithU Yamaha RNF (YZR-M1) | +19.201s |
| 16 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP) | +25.473s |
| 17 | Fabio Di Giannantonio | ITA | Gresini Ducati (GP21)* | +27.006s |
| 18 | Raul Fernandez | SPA | KTM Tech3 (RC16)* | +29.374s |
| 19 | Remy Gardner | AUS | KTM Tech3 (RC16)* | +29.469s |
| 20 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +43.294s |
| Francesco Bagnaia | ITA | Ducati Lenovo (GP22) | DNF | |
| Alex Rins | SPA | Suzuki Ecstar (GSX-RR) | DNF | |
| Darryn Binder | RSA | WithU Yamaha RNF (YZR-M1)* | DNF | |
| Takuya Tsuda | JPN | Suzuki Ecstar (GSX-RR) | DNF | |
| Tetsuta Nagashima | JPN | HRC Team (RC213V) | DNF |