Jorge Martin, zawodnik Prima Pramac Ducati z czasem 01’47.402 ustanowił najszybszy rezultat podczas drugiego treningu wolnego do Grand Prix Aragonii. Drugi czas uzyskał aktualny mistrz Świata i lider klasyfikacji generalnej Fabio Quartararo, trzeci czas ustanowił Johann Zarco, kolega zespołowy Jorge Martina.
| POS | RIDER | NAT | TEAM | TIME/DIFF | LAP | MAX | |
| 1 | ^11 | Jorge Martin | SPA | Pramac Ducati (GP22) | 1’47.402s | 16/18 | 346k |
| 2 | ^6 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +0.074s | 16/18 | 344k |
| 3 | ^2 | Johann Zarco | FRA | Pramac Ducati (GP22) | +0.107s | 18/19 | 344k |
| 4 | ^2 | Enea Bastianini | ITA | Gresini Ducati (GP21) | +0.181s | 17/17 | 350k |
| 5 | ˅3 | Francesco Bagnaia | ITA | Ducati Lenovo (GP22) | +0.237s | 18/18 | 350k |
| 6 | ˅3 | Alex Rins | SPA | Suzuki Ecstar (GSX-RR) | +0.263s | 17/19 | 344k |
| 7 | ^8 | Maverick Viñales | SPA | Aprilia Racing (RS-GP) | +0.276s | 15/17 | 344k |
| 8 | ^3 | Marc Marquez | SPA | Repsol Honda (RC213V) | +0.359s | 14/15 | 346k |
| 9 | ^4 | Jack Miller | AUS | Ducati Lenovo (GP22) | +0.398s | 16/16 | 346k |
| 10 | = | Luca Marini | ITA | Mooney VR46 Ducati (GP22) | +0.491s | 3/17 | 346k |
| 11 | ˅7 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +0.509s | 16/19 | 341k |
| 12 | ^8 | Brad Binder | RSA | Red Bull KTM (RC16) | +0.510s | 15/16 | 345k |
| 13 | ˅12 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP) | +0.549s | 4/12 | 344k |
| 14 | ˅5 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +0.600s | 15/17 | 344k |
| 15 | ˅8 | Miguel Oliveira | POR | Red Bull KTM (RC16) | +0.640s | 17/17 | 343k |
| 16 | ^5 | Fabio Di Giannantonio | ITA | Gresini Ducati (GP21)* | +0.827s | 14/15 | 344k |
| 17 | ˅3 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP21)* | +1.073s | 16/16 | 345k |
| 18 | = | Alex Marquez | SPA | LCR Honda (RC213V) | +1.119s | 4/17 | 341k |
| 19 | ˅3 | Cal Crutchlow | GBR | WithU Yamaha RNF (YZR-M1) | +1.129s | 18/18 | 344k |
| 20 | ^4 | Darryn Binder | RSA | WithU Yamaha RNF (YZR-M1)* | +1.216s | 15/17 | 344k |
| 21 | ˅4 | Joan Mir | SPA | Suzuki Ecstar (GSX-RR) | +1.219s | 16/17 | 344k |
| 22 | ^1 | Raul Fernandez | SPA | KTM Tech3 (RC16)* | +1.286s | 3/16 | 345k |
| 23 | ˅4 | Pol Espargaro | SPA | Repsol Honda (RC213V) | +1.341s | 5/18 | 345k |
| 24 | ˅2 | Remy Gardner | AUS | KTM Tech3 (RC16)* | +1.350s | 16/17 |