Maverick Vinales rozpoczął zmagania na torze Termas de Rio Hondo z najszybszym rezultatem podczas pierwszej sesji treningowej Grand Prix Argentyny. Drugie miejsce zajął zeszłoroczny triumfator wyścigu i kolega zespołowy Vinalesa, Aleix Espargaro. Trzeci rezultat ustanowił Jorge Martin.
| POS | RIDER | NAT | TEAM | TIME/DIFF | LAP | MAX |
| 1 | Maverick Viñales | SPA | Aprilia Racing (RS-GP23) | 1’39.207s | 18/20 | 335k |
| 2 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP23) | +0.284s | 18/18 | 336k |
| 3 | Jorge Martin | SPA | Pramac Ducati (GP23) | +0.301s | 18/20 | 334k |
| 4 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +0.376s | 18/19 | 333k |
| 5 | Alex Marquez | SPA | Gresini Ducati (GP22) | +0.403s | 18/19 | 334k |
| 6 | Johann Zarco | FRA | Pramac Ducati (GP22) | +0.421s | 16/17 | 334k |
| 7 | Luca Marini | ITA | Mooney VR46 Ducati (GP22) | +0.426s | 15/18 | 333k |
| 8 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +0.489s | 15/16 | 334k |
| 9 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP22) | +0.493s | 15/20 | 335k |
| 10 | Francesco Bagnaia | ITA | Ducati Lenovo (GP23) | +0.544s | 17/18 | 337k |
| 11 | Alex Rins | SPA | LCR Honda (RC213V) | +0.595s | 16/17 | 335k |
| 12 | Fabio Di Giannantonio | ITA | Gresini Ducati (GP22) | +0.719s | 17/19 | 331k |
| 13 | Augusto Fernandez | SPA | Tech3 GASGAS (RC16)* | +0.787s | 19/20 | 333k |
| 14 | Jack Miller | AUS | Red Bull KTM (RC16) | +0.830s | 15/17 | 333k |
| 15 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +0.909s | 17/19 | 334k |
| 16 | Brad Binder | RSA | Red Bull KTM (RC16) | +1.057s | 19/19 | 332k |
| 17 | Raul Fernandez | SPA | RNF Aprilia (RS-GP22) | +1.129s | 16/18 | 331k |
| 18 | Joan Mir | SPA | Repsol Honda (RC213V) | +1.458s | 18/19 | 331k |