Poniżej przedstawiamy wyniki wyścigu głównego Grand Prix Katalonii na torze w Barcelonie.
| Pos | Rider | Nat | Team | Time/Diff |
| 1 | Francesco Bagnaia | ITA | Ducati Lenovo (GP24) | 40m 11.726s |
| 2 | Jorge Martin | SPA | Pramac Ducati (GP24) | +1.740s |
| 3 | Marc Marquez | SPA | Gresini Ducati (GP23) | +10.491s |
| 4 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP24) | +10.543s |
| 5 | Fabio Di Giannantonio | ITA | VR46 Ducati (GP23) | +15.441s |
| 6 | Raul Fernandez | SPA | Trackhouse Aprilia (RS-GP23) | +15.916s |
| 7 | Alex Marquez | SPA | Gresini Ducati (GP23) | +16.882s |
| 8 | Brad Binder | RSA | Red Bull KTM (RC16) | +18.578s |
| 9 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +20.477s |
| 10 | Miguel Oliveira | POR | Trackhouse Aprilia (RS-GP24) | +20.889s |
| 11 | Marco Bezzecchi | ITA | VR46 Ducati (GP23) | +21.023s |
| 12 | Maverick Viñales | SPA | Aprilia Racing (RS-GP24) | +22.137s |
| 13 | Pedro Acosta | SPA | Red Bull GASGAS Tech3 (RC16)* | +31.967s |
| 14 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +32.987s |
| 15 | Joan Mir | SPA | Repsol Honda (RC213V) | +33.132s |
| 16 | Johann Zarco | FRA | LCR Honda (RC213V) | +34.554s |
| 17 | Luca Marini | ITA | Repsol Honda (RC213V) | +36.689s |
| 18 | Enea Bastianini | ITA | Ducati Lenovo (GP24) | +50.615s |
| 19 | Stefan Bradl | GER | HRC Test Team (RC213V) | +55.295s |
| 20 | Alex Rins | SPA | Monster Yamaha (YZR-M1) | +63.428s |
| Franco Morbidelli | ITA | Pramac Ducati (GP24) | DNF | |
| Augusto Fernandez | SPA | Red Bull GASGAS Tech3 (RC16) | DNF | |
| Jack Miller | AUS | Red Bull KTM (RC16) | DNF |